GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs199347 | 1 | rs858239 | chr7:23286315 | GPNMB | chr7:23286316-23314728:+ | -0.26 | -4.27 | 2.48E-5 | Parkinson's disease |
| BLCA | cis | rs199347 | 1 | rs858240 | chr7:23284237 | GPNMB | chr7:23286316-23314728:+ | -0.25 | -4.15 | 4.09E-5 | Parkinson's disease |
| BLCA | cis | rs9369898 | 1 | rs8589 | chr6:49403282 | CENPQ | chr6:49431096-49460820:+ | -0.39 | -8.57 | 2.55E-16 | Homocysteine levels |
| BLCA | cis | rs10461617 | 1 | rs860580 | chr5:56149429 | C5orf35 | chr5:56205103-56213010:+ | -0.73 | -11.67 | 3.82E-27 | Type 2 diabetes |
| BLCA | cis | rs10461617 | 1 | rs861283 | chr5:56184610 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 11.53 | 1.32E-26 | Type 2 diabetes |
| BLCA | cis | rs10461617 | 1 | rs863840 | chr5:56128999 | C5orf35 | chr5:56205103-56213010:+ | 0.71 | 11.05 | 7.82E-25 | Type 2 diabetes |
| BLCA | cis | rs10461617 | 1 | rs866222 | chr5:56184444 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 11.53 | 1.32E-26 | Type 2 diabetes |
| BLCA | cis | rs8133949 | 1 | rs871546 | chr21:43413553 | C21orf121 | chr21:43442113-43445060:+ | 0.29 | 4.13 | 4.49E-5 | Hand grip strength |
| BLCA | cis | rs13256369 | 1 | rs873063 | chr8:8572447 | CLDN23 | chr8:8559666-8561616:+ | -0.23 | -3.94 | 9.88E-5 | Obesity-related traits |
| BLCA | cis | rs13256369 | 1 | rs873064 | chr8:8572380 | CLDN23 | chr8:8559666-8561616:+ | -0.23 | -3.94 | 9.88E-5 | Obesity-related traits |
| BLCA | cis | rs2130392 | 1 | rs873686 | chr4:185638876 | MLF1IP | chr4:185615220-185655286:- | 0.48 | 11.15 | 3.49E-25 | Kawasaki disease |
| BLCA | cis | rs56322409 | 1 | rs8758 | chr10:97366107 | ENTPD1 | chr10:97471536-97637022:+ | 0.2 | 5 | 8.71E-7 | Blood metabolite levels |
| BLCA | cis | rs877636 | 1 | rs877636 | chr12:56480583 | RPS26 | chr12:56435686-56438005:+ | -0.46 | -7.82 | 5.14E-14 | Cognitive function |
| BLCA | cis | rs2531995 | 1 | rs879620 | chr16:4015729 | CREBBP | chr16:3775058-3930121:- | 0.19 | 3.85 | 0.000139 | Body mass index;Obesity |
| BLCA | cis | rs881375 | 1 | rs881375 | chr9:123652898 | LOC253039 | chr9:123605320-123616644:+ | -0.35 | -5.95 | 6.1E-9 | Rheumatoid arthritis |